The Anti-OTOP1 Antibody, Rabbit Polyclonal from MyBioSource.com is a Rabbit Polyclonal antibody. This antibody recognizes Human antigen. The Anti-OTOP1 Antibody, Rabbit Polyclonal has been shown to work in the following applications: Immunohistochemistry, and Immunohistochemistry - fixed.
Description
Otopetrins were identified as a novel family of eukaryotic proton channels, with no structural similarity to M2, Hv1 or other ion channels. Otopetrins (Otop1-Otop3) comprise one of two known eukaryotic proton-selective channel families. Otop1 is required for otoconia formation and a candidate mammalian sour taste receptor. Mice have three related genes (Otop1, Otop2 and Otop3) that encode channels with distinct biophysical properties. For example, the current amplitudes of mouse Otop1 and mouse Otop3 increase linearly as a function of extracellular pH over a range of pH 6-pH 4, while the current of mouse Otop2 saturates at ~pH 5. Otop1 has been demonstrated to be proton-selective, with a remarkable >2 x 105-fold selectivity for protons over Na+