MyBioSource.com's Anti-Mllt3 Antibody, Rabbit Polyclonal is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunocytochemistry, and Immunofluorescence.
Description
Human MLLT3 gene, also called AF9 or LTG9, was located at chromosome 9p22 region. It was one of the most common fifty partners fused with the mixed lineage leukemia (MLL) gene at chromosome 11q23, which resulted in translocation t(9;11) (p22;q23). The formed fusion gene MLL-AF9 was the most common chromosomal aberrations in pediatric acute myelogenous leukemia (AML) and acute lymphoblastic leukemia (ALL). The MLLT3 gene was >100 kb and contained a serine/proline-rich domain as well as a nuclear localization signal. It was shown to function as a transcription activator and might be involved in the activity of RNA polymerase II, elongated transcription of target genes and chromatin remodeling