The Anti-PPM1D Antibody, Rabbit Polyclonal from MyBioSource.com is a Rabbit Polyclonal antibody. This antibody recognizes Human antigen. The Anti-PPM1D Antibody, Rabbit Polyclonal has been shown to work in the following applications: Immunocytochemistry, and Immunofluorescence.
Description
PPM1D (protein phosphatase Mn2+/Mg2+-dependent 1D) is part of a regulatory feedback loop with p53: activated p53 induces expression of PPM1D, which then both directly and indirectly dephosphorylates p53, leading to downregulation of p53-mediated apoptosis. PPM1D has been found to be amplified and overexpressed in a significant fraction of medulloblastoma, breast cancer, and ovarian cancer. Mutations in PPM1D are typically nonsense or frameshift mutations in the sixth exon, which produce a C-terminal truncated protein. PPM1D mutations have been noted in patients with hematologic conditions, specifically therapy-related myelodysplastic syndrome