MyBioSource.com's Rabbit Anti-EAAT1/SLC1A3 Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, and Immunohistochemistry - fixed. The Rabbit Anti-EAAT1/SLC1A3 Antibody was generated using SLC1A3 as the antigen and it reacts with Mouse.
Description
The SLC1A3 (Solute Carrier Family 1, member 3) gene encodes a glial glutamate transporter-excitatory amino-acid transporter 1, which is a trimeric transmembrane protein responsible for glutamate transport in the synaptic cleft and maps to chromosome 5p12, a region of linkage that coincides in two published ADHD genome scans so far. SLC1A3 is thus both a functional and positional candidate gene for ADHD. Episodic ataxia type 6 (EA6) is caused by mutations in SLC1A3 that encodes excitatory amino acid transporter 1 (EAAT1), a glial glutamate transporter. EAAT1 regulates the extent and duration of the glutamate-mediated signal by the clearance of glutamate after synaptic release. Besides, EAAT1 also has an anion channel activity that prevents additional glutamate release. p53 promotes the expression of SLC1A3, which allows the utilization of aspartate to support cells in the absence of extracellular glutamine