MyBioSource.com's Anti-ATXN7L1 Antibody, Rabbit Polyclonal is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, and Immunohistochemistry - fixed.
Description
Ataxin 7 (ATXN7) is a protein of the SCA7 gene, which contains 892 amino acids with an expandable poly(Q) region close to the N-terminus. ATXN7-L1 (Ataxin 7 like protein 1), ATXN7-L2 and ATXN7-L3 are paralogues of ATXN7. ATXN7 is found in the cytoplasm of all the populations of neurons analyzed in control brains, but nuclear labeling is observed in some neurons with a frequency and intensity weakly correlated with the topography of lesions in patients. Ataxin-7 is a component of the Tata binding protein (TBP)-free TAF-containing complex (TFTC) and the SPT3/TAF9/GCN5 acetyltransferase complex (STAGA), which is implicated in several steps of transcriptional regulation such as histone acetylation/deubiquitinylation and recruitment of the preinitiation complex to promoters