MyBioSource.com's Anti-CDKN1C Antibody, Rabbit Polyclonal is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, and Immunohistochemistry - fixed.
Description
CDKN1C is a cyclin-dependent kinase Inhibitor and negative regulator of cellular proliferation. The CDKN1C gene encodes the p57Kip2 protein which has been identified as the third member of the CIP/Kip family. p57Kip2 can bind tightly and inhibit cyclin/cyclin-dependent kinase complexes and, in turn, modulate cell division cycle progression. Loss-of-function variants in CDKN1C are associated with an overgrowth condition (Beckwith-Wiedemann Syndrome) whereas "gain-of-function" variants in CDKN1C that increase protein stability cause growth restriction as part of IMAGe syndrome (Intrauterine growth restriction, Metaphyseal dysplasia, Adrenal hypoplasia, and Genital anomalies). Gain-of-function mutations in the PCNA domain of CDKN1C are the genetic basis of various growth-retarded syndromes including IMAGe syndrome, Russell Silver syndrome as well as a novel undergrowth syndrome that additionally exhibited early adulthood onset diabetes