The Anti-NIN Antibody, Rabbit Polyclonal from MyBioSource.com is a Rabbit Polyclonal antibody. This antibody recognizes Human antigen. The Anti-NIN Antibody, Rabbit Polyclonal has been shown to work in the following applications: Immunohistochemistry, and Immunohistochemistry - fixed.
Description
NIN (Ninein, also known as SCKL7) is located on human chromosome 14q22.1. Ninein possesses an amino-terminal domain that binds to dynein/dynactin, followed by a large coiled-coil-forming central domain. In undifferentiated cells, ninein is bound to the centrosome, and is particularly enriched at the subdistal appendages of the mother centriole and the basal body of the primary cilium, where it binds to microtubule minus-ends. Ninein may act as a centrosome maturation factor and may play a role in microtubule nucleation, by recruiting the gamma-tubulin ring complex to the centrosome. Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules. Required for centriole organization and microtubule anchoring at the mother centriole