MyBioSource.com's Anti-NUFIP1 Antibody, Rabbit Polyclonal is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, and Immunohistochemistry - fixed.
Description
Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) forms a heterodimer with a smaller protein, Zinc finger HIT domain-containing protein 3 (ZNHIT3), whose lysosomal abundance also increased upon Torin1 treatment, albeit to a lesser extent. In the nucleus, NUFIP1 is localized in the nuclear matrix in RNA-containing structures lying in the proximity of, but not overlapping with, sites of nascent RNA. NUFIP1 is also present in the cytoplasm, where it is associated with ribosomes, similarly to FMRP (Fragile X Mental Retardation Protein). In neurons NUFIP1 can be detected in functional synaptoneurosomes, colocalizing with ribosomes. NUFIP1, a protein not previously associated with lysosomes, is necessary for the starvation-induced degradation of ribosomes and it fulfills multiple criteria for being an autophagy receptor for ribosomes