The Anti-IRAK2 Antibody, Rabbit Polyclonal from MyBioSource.com is a Rabbit Polyclonal antibody. This antibody recognizes Human antigen. The Anti-IRAK2 Antibody, Rabbit Polyclonal has been shown to work in the following applications: Immunohistochemistry, and Immunohistochemistry - fixed.
Description
IRAK2 (Interleukin 1 Receptor Associated Kinase 2) is a Protein Coding gene. The IRAK2 gene, located on 3p25.3, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and frog. IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2, a member of the interleukin-1 receptor-associated kinase (IRAK) family, has been implicated in Toll-like receptor (TLR)-mediated signaling. IRAK2 is essential for lipopolysaccharide (LPS)-mediated posttranscriptional control of cytokine and chemokine production. IRAK2 is required for lipopolysaccharide-mediated post-transcriptional control of cytokine and chemokine expression, which plays an essential role in TLR4-induced septic shock. IRAK2 is also reported to participate in the IL1-induced upregulation of NF-kappaB