The Rabbit Anti-FE65/APBB1 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to APBB1. This antibody recognizes Human antigen. The Rabbit Anti-FE65/APBB1 Antibody has been shown to work in the following applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry, and Immunohistochemistry - fixed.
Description
Amyloid beta precursor protein binding family B member 1(APBB1) was first identified as a binding partner of amyloid precursor protein during brain development, That APBB1 regulates activation of nuclear factor-kappaB, which is involved in reducing various stresses including oxidative stress, which suggests that APBB1 is associated with gamma-radiation sensitivity. Our findings imply that APBB1 plays an important role in the maintenance of EMT-associated CSC-like properties and gamma-radiation resistance via activation of IGF1Rbeta/AKT/GSK3beta pathway in lung cancer cells, highlighting APBB1 as a potential target for therapeutic cancer treatment. A genetic polymorphism in intron 13 of the FE65 gene (APBB1) was reported to be associated with Alzheimer's disease (AD)