MyBioSource.com's Anti-SNAP-25 Antibody, Rabbit Polyclonal is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: EIA, Immunoassay, and ELISA. The Anti-SNAP-25 Antibody, Rabbit Polyclonal was generated using SNAP25 as the antigen and it reacts with Human.
Description
Synaptosomal-associated protein 25, also known as Super protein, Synaptosomal-associated 25 kDa protein, SNAP25 and SNAP, is a cytoplasm and cell membrane protein that belongs to the SNAP-25 family. SNAP25/SUP contains 2 t-SNARE coiled-coil homology domains. SNAP25/SUP is a membrane bound protein anchored to the cytosolic face of membranes via palmitoyl side chains in the middle of the molecule. SNAP25/SUP protein is a component of the SNARE complex, which is proposed to account for the specificity of membrane fusion and to directly execute fusion by forming a tight complex that brings the synaptic vesicle and plasma membranes together. SNAP25/SUP is a Q-SNARE protein contributing two alpha-helices in the formation of the exocytotic fusion complex in neurons where it assembles with syntaxin-1 and synaptobrevin. SNAP25/SUP is involved in the molecular regulation of neurotransmitter release. It may play an important role in the synaptic function of specific neuronal systems. SNAP25/SUP associates with proteins involved in vesicle docking and membrane fusion. SNAP25/SUP regulates plasma membrane recycling through its interaction with CENPF. SNAP25/SUP inhibits P/Q-and L-type voltage-gated calcium channels located presynaptically and interacts with the synaptotagmin C2B domain in Ca2+-independent fashion. In glutamatergic synapses SNAP25/SUP decreases the Ca2+ responsiveness, while it is naturally absent in GABAergic synapses