MyBioSource.com's Anti-GGT7 Antibody, Rabbit Polyclonal is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, and Immunohistochemistry - fixed.
Description
The gamma-Glutamyl transferase (GGT) family is comprised of 13 enzymes that are involved in glutathione metabolism and whose expressions are altered in numerous human malignancies including breast, uterine, and lung cancer and leukemia. The GGT family modulates crucial redox sensitive functions such as anti-oxidant/anti-toxic defense and cellular proliferative/apoptotic balance. GGT7 (formerly GGTL3, GGTL5) is a novel member of the GGT family. GGT7 shares a 47% and 52% similar amino acid sequence to its more well-characterized family members GGT1 and GGT5, respectively. GGT7 differs from the other GGT isoforms, since it is the only isoform to have ~20-fold higher mRNA expression in the brain compared with other normal tissues and has decreased expression in gliomas compared with the normal brain. GGT7 can be a promising biomarker and a potential therapeutic target for glioblastoma (GBM)