MyBioSource.com's Anti-ZC3H12C Antibody, Rabbit Polyclonal is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, and Immunohistochemistry - fixed.
Description
The CCCH-zinc finger-containing protein family includes four members of MCPIP1 (MCP-induced protein 1)/Zc3h12 (zinc finger CCCH-type-containing 12) a, Zc3h12b, Zc3h12c and Zc3h12d. MCPIP1 is a novel anti-inflammatory protein that can negatively regulate both innate and adaptive immunity, and that its selective expression in lymphoid and inflamed tissues suppresses hyper-responsiveness, thereby contributing to the maintenance of immune homoeostasis. Zc3h12c is a 99 kDa protein comprising 883 amino acids. Similar to MCPIP1/Zc3h12a, Zc3h12c also contains a single CCCH-zinc finger domain at the middle of the protein and an RNase domain at the N-terminus before the CCCH-zinc finger domain. The Zc3h12c gene has been mapped to chromosome 9 in the mouse and the equivalent gene in humans, ZC3H12C, has been mapped to chromosome 11q22.3