MyBioSource.com's Anti-HERC2 Antibody, Rabbit Polyclonal is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, and Immunohistochemistry - fixed.
Description
HERC2, a HECT E3 ligase, is critical for their functions to suppress G-quadruplex (G4) DNA. HERC2 interacted with BLM, WRN, and replication protein A (RPA) complexes during the S-phase of the cell cycle. HERC2 is a master regulator of G-quadruplex, a DNA secondary structure that triggers genomic instability. HERC2 belongs to the large HERC family of ubiquitin E3 ligases. Members of this family contain more than one regulator of chromosome condensation 1 (RCC1)-like domain (RLD) and a homologous to the E6AP carboxyl terminus (HECT) ubiquitin ligase domain. HERC2 is the only member of this small family that contains a p53-binding domain named CPH due to its presence in cullin 7 (CUL7), Parkin-like cytoplasmic (PARC), and HERC2 itself. Mutations of HERC2 are implicated in the pathogenesis of various cancers and result in severe neurological conditions in Herc2-mutant mice