MyBioSource.com's Anti-GRM1 Antibody, Rabbit Polyclonal is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, and Immunohistochemistry - fixed. The Anti-GRM1 Antibody, Rabbit Polyclonal was generated using GRM1 as the antigen and it reacts with Mouse, and Rat.
Description
GRM1 gene, which is located on 6q24.3, encodes the metabotropic glutamate receptor type 1 (mGluR1), a transmembrane protein highly expressed in cerebellar Purkinje cells. Pathogenic variants in GRM1 have been reported only three times in humans, causing autosomal-recessive cerebellar ataxia with an early-onset and intellectual disability or dominant forms of cerebellar ataxia with a less severe phenotype in adults. GRM1 cause a recessive form of cerebellar ataxia, SCAR13. A neuronal receptor, GRM1, when ectopically expressed in melanocytes, induces in vitro melanocytic transformation and spontaneous malignant melanoma development in vivo in a transgenic mouse model. GRM1 signaling has been implicated in benign and malignant disorders including prostate cancer (PCa). GRM1 encodes the metabotropic glutamate receptor 1 (mGluR1), whose documented role as a modulator of neuronal signaling and synaptic plasticity makes it a plausible schizophrenia candidate