MyBioSource.com's Anti-MAPRE1 Antibody, Rabbit Polyclonal is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, and Immunohistochemistry - fixed.
Description
MAPRE1 gene is a and prognostic biomarker in breast cancer. High MAPRE1 levels correlate with tumor malignancy, high histological grade, and poor clinical outcome. The combination of high-MAPRE1 and low-MTUS1 levels in tumors is significantly associated with tumor aggressiveness and reduced patient survival. The APC-binding protein MAPRE1 as a potential colorectal cancer biomarker. MAPRE1 can contribute to the detection of early-stage colorectal cancer and adenomas together with other biomarkers. MicroRNA-10b gene (miR-10b) methylation was associated with an increase in expression of the oncogene that encodes a microtubule-associated protein, RP/EB family, member 1 (MAPRE1; P = 0.004), which was identified as a potential miR-10b target. Transfection with precursor miR-10b into gastric cancer cells dramatically decreased MAPRE1 mRNA and protein, resulting in a significant decrease in colony formation and cell growth rates