The Rabbit Anti-ERM/ETV5 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to ETV5. This antibody recognizes Human antigen. The Rabbit Anti-ERM/ETV5 Antibody has been shown to work in the following applications: Immunohistochemistry, and Immunohistochemistry - fixed.
Description
The ETS family of transcription factors is involved in several normal remodeling events and pathological processes including tumor progression. ETS transcription factors are divided into subfamilies based on the sequence and location of the ETS domain. ETV5 (Ets variant gene 5; also known as ERM) is a member of the PEA3 subfamily. Like other ETS proteins, Etv5 recognizes and binds GGAA/T, the Ets specific consensus sequence, through the Ets domain. Etv5 is involved in cell development. Etv5 expression is increased by IL-12/STAT4 signaling, not by IFNgamma-STAT1 signaling during Th1 cell development. Etv5 increases IL-10 production in vitro and in vivo by binding the Il10 locus and recruiting IL-10 inducing transcription factors