MyBioSource.com's Rabbit Anti-DNA-PKcs/PRKDC Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunocytochemistry, Immunofluorescence, Immunohistochemistry, and Immunohistochemistry - fixed. The Rabbit Anti-DNA-PKcs/PRKDC Antibody was generated using PRKDC as the antigen and it reacts with Human.
Description
PRKDC encodes for DNA-dependent protein kinase catalytic subunit (DNA-PKcs), a kinase that forms part of a complex (DNA-dependent protein kinase [DNA-PK]) crucial for DNA double-strand break repair and V(D)J recombination. PRKDC expression was significantly increased in breast cancer tissue samples compared with NATs. High PRKDC expression was associated with higher tumor grade (P=0.001), positive lymph node metastasis (P=0.0357) and chemoresistance (P=0.0006). Furthermore, PRKDC expression was significantly correlated with OS in breast cancer patients with (0.0101) or without (P=0.0216) receiving chemotherapy. Collectively, PRKDC is a prognostic biomarker for chemoresistance in breast cancer patients