The Anti-FBXO28 Antibody, Rabbit Polyclonal from MyBioSource.com is a Rabbit Polyclonal antibody to F-box protein 28. This antibody recognizes Human antigen. The Anti-FBXO28 Antibody, Rabbit Polyclonal has been shown to work in the following applications: Immunocytochemistry, Immunofluorescence, and Western Blot.
Description
The F-box protein is the substrate recognition subunit of SCF (SKP1/CUL1/F-box) E3 ubiquitin ligase complex, a multicomponent RING-type E3 ligase involved in the regulation of numerous cellular processes by targeting critical regulatory proteins for ubiquitination. F-box protein 28 (FBXO28), a substrate-recruiting component of the Skp1-Cul1-F-box (SCF) ligase complex, is a regulator of pancreatic beta-cell survival. FBXO28 is an important nuclear F-box protein. FBXO28 is involved in cell cycle regulation and required for appropriate mitotic progression. Loss of FBXO28 results in metaphase to anaphase progression delay, which then leads to several mitotic defects like lagging chromosomes, multipolar spindles and multi-nucleation