The Anti-Kctd17 Antibody, Rabbit Polyclonal from MyBioSource.com is a Rabbit Polyclonal antibody. This antibody recognizes Human antigen. The Anti-Kctd17 Antibody, Rabbit Polyclonal has been shown to work in the following applications: Immunohistochemistry, and Immunohistochemistry - fixed.
Description
KCTD17, which is up-regulated in liver tissues of obese mice and patients with obesity-induced nonalcoholic fatty liver disease (NAFLD), binds to phosphorylated PHLPP2 to target it for ubiquitin-mediated degradation; this increases expression of genes that regulate lipogenesis to promote hepatic steatosis. KCTD17 encodes for a member of a recently identified family of 26 closely related and highly conserved proteins, the potassium channel tetramerization domain (KCTD)-containing proteins. KCTD proteins are characterized by the presence of a N-terminal bric-a-brack, tram-track, broad complex/poxvirus zinc finger (BTB/POZ) domain, homologous to the cytoplasmic domain T1 of voltage-gated potassium channels. Despite the homology reflected in their names, a direct interaction with potassium channels has not been shown for most members of the family and was explicitly excluded for KCTD5, a paralog 85% identical to KCTD17