MyBioSource.com's Anti-PDE1A Antibody, Rabbit Polyclonal is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, and Immunohistochemistry - fixed.
Description
A reduction in intracellular calcium causes an increase in intracellular cAMP and PKA activity through stimulation of calcium inhibitable adenylyl cyclase 6 and inhibition of phosphodiesterase 1 (PDE1), the main enzymes generating and degrading cAMP in the distal nephron and collecting duct. PDE1, a subfamily of cyclic nucleotide PDEs consisting of three isoforms, PDE1A, PDE1B and PDE1C, regulates vascular tone. The PDE1A gene spans over 120 kb of genomic DNA, and consists of at least 17 exons and 16 introns. PDE1A is the dominant PDE1 isoform present in vascular smooth muscle cells (VSMCs), and relaxation mediated by PDE1A inhibition is predominantly driven by enhanced cGMP signalling