Anti-OBSCN Antibody, Rabbit Polyclonal from MyBioSource.com

The giant multifunctional protein "OBSCURIN" is encoded by the OBSCN gene and is mostly expressed in cardiac and other skeletal muscles responsible for myofibrils organization. Obscurins, encoded by the single OBSCN gene, are giant cytoskeletal proteins with structural and regulatory roles. The single mammalian obscurin gene, OBSCN, gives rise to giant (~800 kDa) and smaller (~40-500 kDa) proteins that are composed of tandem adhesion and signaling motifs. Mammalian obscurin proteins are expressed in a variety of cell types, including striated muscles, and localize to distinct subcellular compartments. Loss of OBSCURIN affects the entire downstream pathway proteins vital for various cellular functions including cell integration and cell adhesion. The OBSCN gene mutations are more frequently observed in various muscular diseases and cancers. Loss of giant obscurins from breast epithelial cells confers them with a survival and growth advantage, following exposure to DNA-damaging agents