MyBioSource.com's Rabbit Anti-MuRF1/TRIM63 Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunocytochemistry, Immunofluorescence, and Western Blot. The Rabbit Anti-MuRF1/TRIM63 Antibody was generated using TRIM63 as the antigen and it reacts with Human.
Description
TRIM63, also called muscle-specific ring finger protein 1 (MuRF1), was reported to be an E3 ubiquitin ligase expressed mainly in muscular tissue. SaOS2 cells overexpressing exogenous TRIM63 showed increased expression of an osteoblastic differentiation marker gene, alkaline phosphatase, with reduced proliferation. That TRIM63 is a candidate for genes mediating the glucocorticoid-induced promotion of osteoblastic differentiation. TRIM63 encoding Muscle RING Finger 1 (MuRF1) maintains muscle protein homeostasis by tagging the sarcomere proteins with ubiquitin for subsequent degradation by the ubiquitin-proteasome system (UPS)