MyBioSource.com's Anti-OTUD6B Antibody, Rabbit Polyclonal is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunoprecipitation, and Western Blot.
Description
Deubiquitinating enzymes (or DUBs) are involved in the regulation of central biological processes, including DNA repair, apoptosis, oncogene expression and function, and checkpoint regulation. DUBs are classified in five groups including the ovarian tumor domain-containing DUBs (OTU family), which comprises enzymes that can display linkage-specificity in their recognition and cleavage of diubiquitin moieties. The OTUD6B gene (located on chromosome 8q21.3, 17 kb long) encodes a member of the ovarian tumor domain (OTU)-containing subfamily of deubiquitinating enzymes. OTUD6B shows a widespread expression pattern (The GTEx Portal1), and its primary transcript can be alternatively spliced to produce two main different splicing variants. The first isoform (NM_016023.3, OTUD6B-1) is characterized by seven exons with the start codon in the first one, whereas isoform 2 (NM_001286745.1, OTUD6B-2) includes an additional out-of-frame exon (from here named exon 3) that leads to a premature stop just after three residues. In non-small cell lung cancer, the two main OTUD6B isoforms have been shown to have opposite effects on global protein synthesis and DNA synthesis, with OTUD6B-1 stimulating protein and DNA synthesis and OTUD6B-2 repressing both processes. Biallelic mutations in the OTUD6B gene, were reported to cause an intellectual disability syndrome characterized by seizures and dysmorphic features