MyBioSource.com's Anti-SLC44A3 Antibody, Rabbit Polyclonal is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, and Immunohistochemistry - fixed.
Description
Choline transporter-like proteins CTLs/SLC44 family are highly expressed in various cancer cell lines. Members of this family are encoded by five genes (CTL1-CTL5) with further diversity occurring through alternative splicing of CTL1, 4 and 5. CTL family members are putative 10TM domain proteins with extracellular termini that mediate Na+ -independent transport of choline with an affinity that is intermediate to that of the high-affinity choline transporter CHT1 (SLC5A7) and the low-affinity organic-cation transporters [OCT1 (SLC22A1) and OCT2 (SLC22A2). CLT1 is expressed almost ubiquitously in human tissues and mediates choline transport across the plasma and mitochondrial membranes. Transport of choline by CTL2, which in rodents is expressed as two isoforms (CTL2P1 and CLTP2) in lung, colon, inner ear and spleen and to a lesser extent in brain, tongue, liver, and kidney