The Anti-LIMCH1 Antibody, Rabbit Polyclonal from MyBioSource.com is a Rabbit Polyclonal antibody. This antibody recognizes Human antigen. The Anti-LIMCH1 Antibody, Rabbit Polyclonal has been shown to work in the following applications: Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot.
Description
LIM and calponin-homology domains 1 (LIMCH1) was identified from a border cell migration screen based on conditional ectopic expression in Drosophila. LIMCH1 protein is recruited into contractile stress fibers through its interaction with NM-IIA. Loss of LIMCH1 expression reduces MRLC phosphorylation and assembly. Furthermore, LIMCH1 depletion affects the formation of actin stress fibers as well as the stability of focal adhesions, leading to an increase in cell spreading and migration. LIMCH1 plays a positive role in the spatiotemporal regulation of NM-II activity to modulate cell membrane protrusion and focal adhesion dynamics during cell migration