The Anti-PNMT Antibody, Rabbit Polyclonal from MyBioSource.com is a Rabbit Polyclonal antibody. This antibody recognizes Human antigen. The Anti-PNMT Antibody, Rabbit Polyclonal has been shown to work in the following applications: Immunoprecipitation, and Western Blot.
Description
PNMT (phenylethanolamine-N-methyl-transferase) is the enzyme that catalyzes the formation of epinephrine from norepinephrine and thus serves as a marker of adrenergic cells. PNMT is the final enzyme in the catecholamine synthesizing cascade that converts noradrenaline (NA) to adrenaline (ADR). Both of these catecholamines are physiologically important hormones and neurotransmitters in mammals with profound influence on the activity of the cardiovascular system. PNMT is the rate-limiting enzyme in the synthesis of epinephrine and a specific marker for adrenergic neurons. The activity of human PNMT is reduced in the neurons of those cells in many subcortical areas of the brain that are known to undergo neurodegeneration in Alzheimer's disease (AD)