MyBioSource.com's Anti-NEMF Antibody, Rabbit Polyclonal is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, and Immunohistochemistry - fixed.
Description
The NEMF gene encodes a protein that acts as a 'rescue factor' to resolve stalled ribosomes that occur during translation. NEMF, known as Rqc2 in yeast, recognizes these aberrant stalled structures and facilitates the recruitment of the E3 ligase LTN1, which in turn ubiquitinates the nascent chain of incomplete peptides, leading to their proteasomal degradation. NEMF is part of the 'Ribosome-associated Quality Control' (RQC) complex. In ribosome-associated quality control (RQC), Rqc2/NEMF closely supports the E3 ligase Ltn1/listerin in promoting ubiquitylation and degradation of aberrant nascent-chains obstructing large (60S) ribosomal subunits-products of ribosome stalling during translation