The Anti-NXF1 Antibody, Rabbit Polyclonal from MyBioSource.com is a Rabbit Polyclonal antibody. This antibody recognizes Human antigen. The Anti-NXF1 Antibody, Rabbit Polyclonal has been shown to work in the following applications: Immunocytochemistry, Immunofluorescence, Immunoprecipitation, and Western Blot.
Description
The Nxf1 protein is a major nuclear export receptor for the transport of mRNA, and it also is essential for the export of retroviral mRNAs with retained introns. In the latter case, it binds to RNA elements known as constitutive transport elements and functions in conjunction with a cofactor known as Nxt1. The NXF1 gene also regulates the expression of its intron-containing RNA through the use of a functional CTE within intron 10. mRNA containing this intron is exported to the cytoplasm. NXF1 is a modular protein constructed from four domains (RRM, LRR, NTF2-like, and UBA domains). NXF1 exports mRNA to the cytoplasm after recruitment to mRNA by specific adaptor proteins. In human cells, the mRNA export factor NXF1 resides in the nucleoplasm and at nuclear pore complexes. Karyopherin beta2 or transportin recognizes a proline-tyrosine nuclear localization signal (PY-NLS) in the N-terminal tail of NXF1 and imports it into the nucleus