MyBioSource.com's Anti-CYP24A1 Antibody, Rabbit Polyclonal is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunocytochemistry, Immunofluorescence, Immunoprecipitation, and Western Blot.
Description
CYP24A1, encoding the vitamin D-24-hydroxylase, is of major clinical and physiologic importance, serving to regulate the catabolism of 1, 25-(OH)2D, the physiologically active vitamin D metabolite. In addition to facilitating catabolism of 1, 25-(OH)2D, CYP24A1 also enhances the turnover and elimination of 25-OHD, the abundant precursor metabolite and storage form of the vitamin. CYP24A1, the main enzyme responsible for the degradation of active vitamin D, plays an important role in many cancer related cellular processes. Loss-of-function mutations in the CYP24A1 gene, which encodes the vitamin D-24 hydroxylase, have been recognized as a cause of elevated 1, 25-dihydroxy vitamin D concentrations, hypercalcemia, hypercalciuria, nephrocalcinosis, and nephrolithiasis in infants and adults. CYP24A1, is the primary inactivating enzyme for vitamin D, potentially neutralizing the antitumor effects of calcitriol, the active form of vitamin D