MyBioSource.com's Anti-KMO Antibody, Rabbit Polyclonal is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, and Immunohistochemistry - fixed.
Description
Kynurenine 3-monooxygenase (KMO) is an essential enzyme of the kynurenine pathway, converting kynurenine into 3-hydroxykynurenine. Inhibition of KMO increases kynurenine, resulting in elevated levels of kynurenic acid (KYNA), an endogenous N-methyl-d-aspartate, and alpha*7-nicotinic receptor antagonist. The concentration of KYNA is elevated in the brain of patients with schizophrenia, possibly as a result of a reduced KMO activity. KMO is the ideal target for an inhibitor since inhibition of it would be expected to decrease the toxic metabolites and increase kynurenic acid (KYNA), which is neuroprotective. The first generation of KMO inhibitors was based on structural analogs of the substrate, L-kynurenine. These compounds showed a reduction of QUIN and increased KynA in vivo in rats. Modulation of KMO activity has been implicated in several neurodegenerative diseases, including Huntington's disease