MyBioSource.com's Rabbit Anti-KIAA1524 Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, and Immunohistochemistry - fixed.
Description
Cancerous inhibitor of protein phosphatase 2A (CIP2A) supports the activity of several critical cancer drivers (Akt, MYC, E2F1) and promotes malignancy in most cancer types via PP2A inhibition. In cancer cells, PP2A inhibition results in hyperphosphorylation of a large number of oncogenic drivers and synergizes with other oncogenic events, such as constitutive RAS activity. Importantly, PP2A complex components are mutated at a relatively low frequency in most types of human cancer. high CIP2A protein expression predicts poor patient survival in over a dozen different cancer types 20, and thus, its prognostic and functional relevance equals, or exceeds, that of most oncoproteins that have been traditionally considered important oncogenic drivers