The Rabbit Anti-NIPP1/Ppp1r8 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to PPP1R8. This antibody recognizes Human antigen. The Rabbit Anti-NIPP1/Ppp1r8 Antibody has been shown to work in the following applications: Western Blot.
Description
The ubiquitously expressed nuclear protein NIPP1 (also known as PPP1R8) recruits phosphoproteins for regulated dephosphorylation by the associated protein phosphatase PP1. The deletion of NIPP1 in mice is early embryonic lethal, which has precluded functional studies in adult tissues. Nuclear Inhibitor of PP1 (NIPP1; 351 residues in mouse), encoded by Ppp1r8, is one of the major nuclear interactors of PP1 and is expressed in nearly all eukaryotic cells. The N-terminal third of NIPP1 largely consists of a well-structured ForkHead-Associated (FHA) domain, while the remainder of the protein is intrinsically disordered but becomes partially structured upon binding to PP1. The FHA domain of NIPP1 mediates the recruitment of a subset of phosphoproteins, including the pre-mRNA splicing factors SAP155 and CDC5L, protein kinase MELK and the methyltransferase EZH2, for regulated dephosphorylation by associated PP1