MyBioSource.com's Anti-SAP30 Antibody, Rabbit Polyclonal is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunocytochemistry, Immunofluorescence, and Western Blot. The Anti-SAP30 Antibody, Rabbit Polyclonal was generated using SAP30 as the antigen and it reacts with Human.
Description
The SAP30 protein is a component of the histone deacetylase complex, which includes SIN3, SAP18, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This complex is active in deacetylating core histone octamers, but inactive in deacetylating nucleosomal histones. SAP30 plays a vital role in transcriptional regulation, which can be either negative or positive, depending on local factors, such as chromatin state and the presence of various interacting partners. Mammals have one paralog of SAP30, named SAP30-like (SAP30L), which shares 70% sequence identity with SAP30. SAP30 and SAP30L together constitute a well-conserved SAP30 protein family. Also SAP30L interacts with several components of the Sin3A corepressor complex and induces transcriptional repression via recruitment of Sin3A and histone deacetylases