The Rabbit Anti-Alkaline phosphatase Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to ALPI. This antibody recognizes Human antigen. The Rabbit Anti-Alkaline phosphatase Antibody has been shown to work in the following applications: EIA, Immunoassay, and ELISA.
Description
ALPI encodes for intestinal phosphatase alkaline, a brush border metalloenzyme that hydrolyses phosphate from the lipid A moiety of lipopolysaccharides and thereby drastically reduces Toll-like receptor 4 agonist activity. ALPI mutations impaired either stability or catalytic activity of ALPI and rendered it unable to detoxify lipopolysaccharide-dependent signalling. ALPI mutations should be included in screening for monogenic causes of inflammatory bowel diseases and lay the groundwork for ALPI-based treatments in intestinal inflammatory disorders