MyBioSource.com's Anti-METTL20 Antibody, Rabbit Polyclonal is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, and Immunohistochemistry - fixed.
Description
METTL20 was the first mitochondrial lysine MTase (KMT) to be discovered. METTL20 specifically methylates the beta subunit (ETFB) of electron transfer flavoprotein (ETF), which acts as a mobile carrier of electrons from several flavin adenine dinucleotide-containing dehydrogenases to ETF: quinone oxidoreductase. METTL20 is a seven-beta-strand methyltransferase that is localized to the mitochondria and tri-methylates the electron transfer flavoprotein (ETF) beta subunit (ETFB) at lysines 200 and 203. METTL20 decreases the ability of ETF to extract electrons from medium-chain acyl-coenzyme A (CoA) dehydrogenase (MCAD) and glutaryl-CoA dehydrogenase in vitro. METTL20-mediated ETFB methylation may play a regulatory role in mitochondrial metabolism