The Anti-MYL6B Antibody, Rabbit Polyclonal from MyBioSource.com is a Rabbit Polyclonal antibody to MYL6B. This antibody recognizes Human antigen. The Anti-MYL6B Antibody, Rabbit Polyclonal has been shown to work in the following applications: Western Blot.
Description
MYL6B could facilitate the binding of MDM2 to p53, which consequently promotes the ubiquitination and degradation of p53 protein. MYL6B exerts the suppression effect on p53 as part of NMII holoenzymes because inhibiting the ATPase activity of myosin II heavy chain largely blocked this effect. MYL6B is overexpressed in HCC tissues and linked to the bad prognosis of HCC patients. Knocking out of MYL6B dramatically suppressed the clonogenic ability and increased the apoptosis level of HCC cell lines. MYL6B is a putative tumor driver gene in HCC which could promote the degradation of p53 by enhancing its' MDM2-mediated ubiquitination