Rabbit Anti-ARHGEF25 Antibody from MyBioSource.com

The gene for ARHGEF25 is located on human chromosome 12q13.3, and its expression encodes a Rho-family guanine nucleotide exchange factor (GEF) protein composed of a Dbl homology domain and a pleckstrin homology domain flanked by short N-and C-termini. ARHGEF25 belongs to a family composed of over 60 known human GEFs. This family of proteins serves as enzymes that catalyze the activation of the Rho family of small GTPases through stimulating the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP) on Rho proteins, thus modulating a broad range of cellular processes in eukaryotic cells such as cell proliferation, gene expression, and actin cytoskeletal organization. Three RhoGEF isoforms are produced by the gene ARHGEF25; p63RhoGEF580, GEFT and a recently discovered longer isoform of 619 amino acids (p63RhoGEF⁶¹⁹). The subcellular distribution of p63RhoGEF580 and p63RhoGEF⁶¹⁹ is strikingly different in unstimulated cells, p63RhoGEF580 is located at the plasma membrane and p63RhoGEF⁶¹⁹ is confined to the cytoplasm