MyBioSource.com's Anti-ALDH5A1 Antibody, Rabbit Polyclonal is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunocytochemistry, Immunofluorescence, Immunohistochemistry, and Immunohistochemistry - fixed.
Description
Aldehyde dehydrogenase 5 family, member A1 (ALDH5A1) belongs to the superfamily of aldehyde dehydrogenases (ALDHs). SSADH deficiency (SSADHD) is a rare autosomal recessively inherited metabolic disorder that is associated with mutations of ALDH5A1 gene, coding for the homotetrameric enzyme SSADH. This enzyme is involved in gamma-aminobutyric acid (GABA) catabolism, since it oxidizes succinic semialdehyde (SSA) to succinate. Mutations in ALDH5A1 gene result in the abnormal accumulation of gamma-hydroxybutyrate (GHB), which is pathognomonic of SSADHD. ALDH5A1 is an excellent predictive factor of ovarian cancer and may play crucial roles in ovarian cancer progression