The Anti-ZCCHC4 Antibody, Rabbit Polyclonal from MyBioSource.com is a Rabbit Polyclonal antibody. This antibody recognizes Human antigen. The Anti-ZCCHC4 Antibody, Rabbit Polyclonal has been shown to work in the following applications: Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot.
Description
The CCHC zinc-finger-containing protein ZCCHC4 (UniProt accession number Q9H5U6) is a potential RNA methyltransferase. CCHC zinc-finger-containing proteins are the most common zinc finger proteins in eukaryotes and are well known for their functions in regulating various RNA-dependent biological processes. The CCHC-ZnF domain is one of the canonical nucleic acid-recognition domains in both DNA-and RNA-binding proteins; binding of CCHC zinc-finger-containing protein to target RNAs can regulate gene expression and translation. For example, ZC3H13, a zinc-finger protein, has been reported to regulate nuclear RNA m6A methylation and mouse embryonic stem cell self-renewal. ZCCHC4 gene is conserved in other multicellular model organisms but absent in yeast. ZCCHC4 protein is overexpressed in hepatocellular carcinoma tumors, and ZCCHC4 knockout significantly reduces tumor size in a xenograft mouse model