The Anti-TP53BP1 Antibody, Rabbit Polyclonal from MyBioSource.com is a Rabbit Polyclonal antibody. This antibody recognizes Human antigen. The Anti-TP53BP1 Antibody, Rabbit Polyclonal has been shown to work in the following applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry, and Immunohistochemistry - fixed.
Description
53BP1 (also known as tumor protein 53-binding protein 1, TP53BP1) is a chromatin-associated factor that promotes immunoglobulin class switching and DNA double-strand-break (DSB) repair by non-homologous end joining. To accomplish its function in DNA repair, 53BP1 accumulates at DSB sites downstream of the RNF168 ubiquitin ligase. TP53BP1 and TP53 interact during TP53-mediated transcriptional activation and checkpoint activation in response to DNA damage. Several studies have indicated that TP53BP1 has noncanonical roles in processes, such as spindle formation. DNA damage-dependent interaction between TP53 and TP53BP1 may contribute to lung cancer risk. The TP53BP1 gene may be involved in the development of cancer through disrupting DNA repair. TP53BP1 and MFN1 that encodes a mitochondrial membrane protein are considered to have tumor suppressor gene (TSG) functions