MyBioSource.com's Rabbit Anti-GLUT10/SLC2A10 Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, and Immunohistochemistry - fixed. The Rabbit Anti-GLUT10/SLC2A10 Antibody was generated using SLC2A10 as the antigen and it reacts with Human.
Description
Arterial tortuosity syndrome (ATS) is an autosomal recessive connective tissue disorder, mainly characterized by tortuosity and elongation of the large-and medium-sized arteries with predisposition to stenoses and aneurysms. ATS is caused by mutations in the SLC2A10 gene, encoding for the facilitative glucose transporter 10 (GLUT10) and is described typically in pediatric patients. The loss-of-function mutation in the gene encoding the facilitative glucose transporter GLUT10 (SLC2A10) causes arterial tortuosity syndrome via upregulation of the TGF-beta pathway in the arterial wall, a mechanism possibly causing vascular changes in diabetes. The SLC2A10 gene is an independent risk factor for PAD in type 2 diabetes