MyBioSource.com's Anti-UQCRC1 Antibody, Rabbit Polyclonal is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot. The Anti-UQCRC1 Antibody, Rabbit Polyclonal was generated using UQCRC1 as the antigen and it reacts with Human.
Description
Ubiquinol cytochrome c reductase core protein I (UQCRC1) is a component of the complex III in the respiratory chain and is expressed abundantly in neurons and astrocytes. UQCRC1 may also be important by forming complex III to maintain normal brain ischemic tolerance, learning, and memory. UQCRC1 is a nuclear-encoded protein localized to the inner mitochondrial membrane and plays a key role in influencing mitochondrial function. Increasing evidence supports that UQCRC1 overexpression takes part in cardioprotection. UQCRC1 overexpression protects H9c2 cardiac cells against mimic ischemia/reperfusion injury through mediating PI3K/Akt/GSK-3beta pathway to regulate apoptosis-related proteins. UQCRC1 was downregulated in human colorectal cancer (CRC). Downregulation of UQCRC1 was correlated with increased lymph node metastasis and finally associated with decreased survival in CRC