MyBioSource.com's Rabbit Anti-UBC6e/UBE2J1 Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunoprecipitation, and Western Blot.
Description
Ubiquitin-mediated protein degradation is involved in many cellular processes, including the degradation of unfolded or misfolded proteins in ER through the pathway called endoplasmic reticulum-associated protein degradation (ERAD). To be degraded in proteasomes, first ERAD substrates must be retro-translocated to the cytosol with the involvement of chaperones and components of the protein translocon machinery. Ubiquitination enzymes that are localized at the cytosolic face of the ER membrane then target ERAD substrate for proteasomal degradation. There are only three E2s: Ube2j1, Ube2j2, and Ube2G2 that are implicated in the degradation of ERAD substrates. Ube2j1 and Ube2j2 are the only ER resident E2s which has a short luminal region, a single transmembrane domain and catalytic domain that is oriented toward the cytosol. Ube2G2 lacks both luminal and transmembrane domain and it functions in ERAD from the cytosol