The Rabbit Anti-Sortilin/SORT1 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to SORT1, and sortilin 1. This antibody recognizes Human, Mouse, and Rat antigen. The Rabbit Anti-Sortilin/SORT1 Antibody has been shown to work in the following applications: Immunohistochemistry, and Immunohistochemistry - fixed.
Description
SORT1 is the neuronal receptor for granulin, encoded by the progranulin gene (GRN), a major causal gene for inherited frontotemporal dementia (FTD). Even though sortilin binds and internalizes LDL by receptor-mediated endocytosis, mutations in the SORT1 gene are unlikely to cause autosomal dominant hypercholesterolemia and may only have a marginal effect on plasma LDL cholesterol levels. The SORT1 locus was originally identified by genome-wide association studies of low-density lipoprotein cholesterol (LDL-C) in adults