MyBioSource.com's Anti-VPREB1 Antibody, Rabbit Polyclonal is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Western Blot. The Anti-VPREB1 Antibody, Rabbit Polyclonal was generated using VPREB1 as the antigen and it reacts with Mouse.
Description
VPREB1 gene, a component of the surrogate light chain of the pre-B-cell receptor (pre-BCR), have been observed in childhood B-cell acute lymphoblastic leukemia (B-ALL), and have been suggested to result from recombination activating gene (RAG) activation. Studies show that a low copy number of the VPREB1 gene is related to the pathogenesis of RA and other autoimmune disorders. Moreover, the VpreB1 can act as an enhancer to ensure developmental stage-specific expression of a reporter gene in B lymphocytes in vivo