MyBioSource.com's Rabbit Anti-TMEM132A Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, and Immunohistochemistry - fixed.
Description
Transmembrane protein 132A (TMEM132A, KIAA1583) was first isolated as a novel gene that is enriched during the embryonic and postnatal stages of rat brain development and interacts with GRP78. TMEM132A is a transmembrane glycoprotein consisting of a large extracellular domain in the N-terminal region and a small cytosolic domain in the C-terminal region. Partial deletions of the intracellular domain of TMEM132A had little effect on its expression level and cell-surface localization in transfected HEK293 cells, whereas deletions of the extracellular domain hampered transport to the cell surface. Transmembrane protein 132A (TMEM132A) is a GRP78 binding protein. TMEM132A is an important factor of cell survival in regulating certain ER stress-related gene expression in neuronal cells. Related family members, including TMEM16A, TMEM132A, and TMEM176B, are involved in various biological behaviors