MyBioSource.com's Rabbit Anti-KAP1/TRIM28 Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, Immunohistochemistry - fixed, Immunoprecipitation, and Western Blot. The Rabbit Anti-KAP1/TRIM28 Antibody was generated using TRIM28 as the antigen and it reacts with Human.
Description
Tripartite motif containing 28 (TRIM28) as a transcriptional co-repressor has been reported playing a role in regulating DNA damage response (DDR), cell differentiation, immune response, and tumorigenesis. The germline loss of function mutations in TRIM28 predispose children to Wilms tumour. TRIM28 through its translational suppression of the family of KRAB domain transcription factors in tumor stromal compartments. TRIM28 is a tumor promoter in B-NHL and may be a novel target for drug resistance to Bortezomib. TRIM28 promoted cervical cancer cell growth by activating the mammalian target of rapamycin (mTOR) signaling pathway. that TRIM28 plays a pivotal role in cervical cancer cell proliferation and might serve as a potential therapeutic target