The Anti-UVSSA Antibody, Rabbit Polyclonal from MyBioSource.com is a Rabbit Polyclonal antibody. This antibody recognizes Human antigen. The Anti-UVSSA Antibody, Rabbit Polyclonal has been shown to work in the following applications: Immunohistochemistry, and Immunohistochemistry - fixed.
Description
UV-stimulated scaffold protein A (UVSSA) consists of 709 amino acid residues. UVSSA contains a Vps27/Hrs/STAM (VHS) domain and a conserved domain of unknown function (DUF) 2043 in the N-terminal and C-terminal regions, respectively. After UV irradiation, UVSSA stabilizes CSB and restores the hypophosphorylated form of Pol II (Pol IIa) in collaboration with USP7. UVSSA forms a complex with ubiquitin-specific peptidase 7 (USP7) and is stabilized by interaction with USP7. The central region of UVSSA, which contains the tumor necrosis factor receptor-associated factor (TRAF)-binding motif, is required for the interaction with the N-terminal TRAF domain of USP7