MyBioSource.com's Anti-TM4SF1 Antibody, Rabbit Polyclonal is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, and Immunohistochemistry - fixed.
Description
Transmembrane-4-L-Six-Family member-1 (TM4SF1) is a member of the L6 family and functions as a signal transducer to regulate cell development, activation, growth, and motility. TM4SF1 is a small plasma membrane-associated glycoprotein that is highly and selectively expressed on the plasma membranes of tumor cells, cultured endothelial cells, and, in vivo, on tumor-associated endothelium. Immunofluorescence microscopy also demonstrated TM4SF1 in the cytoplasm and, tentatively, within nuclei. TM4SF1, a tumor-associated antigen that serves as an oncogene, mainly affects tumor invasion and metastasis and is overexpressed in most epithelial cell carcinomas and a potential target for antibody-mediated therapy. TM4SF1 is a tumor suppressor for gastric carcinoma (GC) and a novel prognostic marker for patients with GC. High expression of TM4SF1 predicts poor prognosis of muscle-invasive bladder cancer (MIBC)